LiveTraffic NSW shows the highway is now open to northbound and southbound traffic after a car rolled before 1pm on Tuesday, sparking a multi-agency response.

The driver of the car was seriously injured and has been flown by helicopter to Tamworth hospital for treatment.

Motorists should exercise caution when passing through the stretch of highway four kilometres south of Boggabri.

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A WOMAN has been airlifted to Tamworth hospital after a serious single-vehicle car crash on the Kamilaroi Highway on Tuesday.

The highway remains closed in both directions about four kilometres south of Boggabri, with emergency services still at the scene.

The Westpac Rescue Helicopter Service was called to the car rollover at about 1pm after initial reports the 37-year-old driver was trapped in the car and suffering serious injuries.

The crash sparked a multi-agency response, with ambulance paramedics, police and rescue services rushing to the site.

Emergency services worked to free the woman from the wreckage and she was treated at the scene for multiple injuries to her lower limbs.

The Westpac Rescue Helicopter's critical care team helped stabilise the woman for transport, and she was flown to Tamworth hospital in a stable condition for further treatment.

It is understood she was the only person injured in the single-vehicle crash.

LiveTraffic NSW shows the road is still closed in both directions, and motorists are being urged to avoid the affected stretch of the Kamilaroi Highway or park and wait for the area to be cleared.

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