Police will be working alongside Traffic and Highway Patrol officers to target risky driver behaviour.

Drivers and riders should expect to see more police on rural roads and highways across the region over the coming days.

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Acting region traffic tactician western Acting Inspector Jason Bush from Traffic and Highway Patrol Command said enforcement and education would be the focus of this weekend's operation.

"Excessive speed, fatigue, alcohol and occupant restraints are evident contributing factors to fatal crashes in the western region," Acting Inspector Bush said.

"Alarmingly it can be a combination of those factors."

More than two thirds of all NSW road fatalities occur on rural roads. This year there have been 57 fatalities on roads throughout the western region.

Western region operations manager Detective Chief Inspector Brett Smith said police would continue to target those doing the wrong thing on rural roads.

"Police will show zero tolerance to those who choose to disobey the road rules during this operation," Detective Chief Inspector Smith said.

"We all too often see alcohol, fatigue and speeding result in deaths on our regional roads.

"The action of our police is endeavouring to reduce the road toll. These actions should be expected by road users to ensure family members and loved ones arrive to their destination safely."

The operation comes just days after a one-day blitz across the Oxley police district.

On Wednesday, highway patrol officers carried out Operation Compliance - a high-visibility blitz involving highway officers, general duties police and plain clothes personnel who roamed several towns looking for motorists using a phone behind the wheel, driving with an unsecured load and not wearing a seatbelt.

Police said those offences were targeted by officers because they are factors that cause serious crashes.